The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes.

MDM-2 protein expression in nasopharyngeal carcinomas. Comparative study with p53 protein expression.

Aims-To investigate the immunohistochemical expression of MDM-2 protein in comparison with that of p53 protein in nasopharyngeal carcinomas.Methods-Formalin fixed, paraffin wax embedded tissue from 59 cases of nasopharyngeal carcinoma was stained by immunohistochemistry for MDM-2 and p53 proteins.Results-The tumours were divided histologically into seven cases of keratinising nasopharyngeal car...

Bcl-2 expression in colorectal tumours. Correlation with p53, mdm-2, Rb proteins and proliferation indices.

Immunostaining for bcl-2 protein was performed in 27 colorectal adenomas and 108 colorectal adenocarcinomas. The aim of the study was to determine bcl-2 expression in correlation with p53, mdm-2 and Rb expression, with proliferation indices (Ki-67-LI, PCNA-LI) as well as with conventional clinicopathological variables. A higher proportion of adenomas (30.8%) than carcinomas (16.7%) expressed bc...

The human MDM-2 oncogene is overexpressed in leukemias.

The human homologue of the mouse double minute 2 (MDM-2) gene codes for a cellular protein that forms a complex with the mutant and wild-type p53 protein and modulates its trans-activation activity. Overexpression of the MDM-2 gene in cells increases their tumorigenic potential and overcomes the growth-suppressive activity of p53. Previous reports have shown that the MDM-2 gene is amplified in ...

Inhibition of MDM 2 - Mediated p 53 Ubiquitination and Degradation by Ribosomal Protein

Title : Preclinical efficacy of the MDM 2 inhibitor RG 7112 in MDM 2 amplified and TP 53 wild

Title: Preclinical efficacy of the MDM2 inhibitor RG7112 in MDM2 amplified and TP53 wild-type glioblastomas Authors: Maite Verreault, Charlotte Schmitt, Lauriane Goldwirt, Kristine Pelton, Samer Haidar, Camille Levasseur, Jeremy Guehennec, David Knoff, Marianne Labussiere, Yannick Marie, Azra H. Ligon, Karima Mokhtari, Khe Hoang-Xuan, Marc Sanson, Brian M Alexander, Patrick Y. Wen, Jean-Yves De...